IREB2 Rabbit Polyclonal Antibody (CAB6382)
- SKU:
- CAB6382
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | IREB2 Rabbit Polyclonal Antibody |
SKU: | CAB6382 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 760-963 of human IRP2 (NP_004127.1). |
Sequence: | SIAR NSAA AKYL TNRG LTPR EFNS YGAR RGND AVMT RGTF ANIK LFNK FIGK PAPK TIHF PSGQ TLDV FEAA ELYQ KEGI PLII LAGK KYGS GNSR DWAA KGPY LLGV KAVL AESY EKIH KDHL IGIG IAPL QFLP GENA DSLG LSGR ETFS LTFP EELS PGIT LNIQ TSTG KVFS VIAS FEDD VEIT LYKH GGLL NFVA RKFS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:20 - 1:50 |
Synonyms: | ACO3; IRP2; IRP2AD; NDCAMA; IRE-BP2; IRE-BP 2 |
Positive Sample: | Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 105kDa |
Observed MW: | 105kDa |
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 3658 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |