The IRAK4 Polyclonal Antibody (AG2020) is a valuable tool for research involving Interleukin-1 receptor-associated kinase 4 (IRAK4), a key player in the toll-like receptor signaling pathway. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications. By targeting IRAK4, researchers can investigate its role in immune responses, inflammation, and potential therapeutic interventions in diseases such as autoimmune disorders and inflammatory conditions.IRAK4 is a crucial mediator in the activation of NF-κB and MAPK pathways in response to microbial infections and inflammation.
Its dysregulation has been linked to various diseases, highlighting the importance of studying its function and regulation. The IRAK4 Polyclonal Antibody enables the detection and analysis of IRAK4 protein levels in different cell types, providing insights into its involvement in innate immunity and inflammatory responses. Researchers can utilize this antibody to investigate IRAK4 signaling pathways and potential targets for drug development in immunological and infectious disease research.
Product Name:
IRAK4 Polyclonal Antibody
SKU:
CAB21779
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human IRAK4 (NP_057207.2).
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51135
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IRAK4 Rabbit pAb (CAB21779) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer:3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
