The IRAK4 Polyclonal Antibody (CAB6208) is a valuable tool for researchers studying IRAK4, a critical signaling molecule in the immune response pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to IRAK4 protein, researchers can effectively detect and analyze its expression in various cell types.IRAK4 plays a key role in the activation of inflammatory pathways and is essential for the innate immune response to pathogens. Dysregulation of IRAK4 signaling has been implicated in various inflammatory diseases, making it a promising therapeutic target for conditions such as autoimmune disorders and infectious diseases.
By studying IRAK4 activity, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially develop novel treatment strategies.Overall, the IRAK4 Polyclonal Antibody (CAB6208) is a valuable tool for researchers interested in investigating the role of IRAK4 in immune response regulation and inflammatory diseases. Its high specificity and reactivity make it an ideal choice for studies in immunology and drug development.
Product Name:
IRAK4 Rabbit Polyclonal Antibody
SKU:
CAB6208
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human IRAK4 (NP_057207.2).
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51135
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using IRAK4 Rabbit pAb (CAB6208) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
