The IRAK3 Polyclonal Antibody (CAB5467) is a valuable tool for researchers studying Interleukin-1 receptor-associated kinase 3 (IRAK3), a key regulator of the immune response. This antibody, generated in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications. By binding to the IRAK3 protein, this antibody enables researchers to detect and analyze IRAK3 levels in various cell types, making it ideal for studies in immunology and inflammatory diseases.IRAK3 is a crucial component of the immune system, serving as a negative regulator of inflammatory signaling pathways.
Its role in immune function and inflammation makes it a promising target for research into disorders such as sepsis, autoimmune diseases, and inflammatory conditions. Understanding the function of IRAK3 is essential for developing therapeutic strategies that can modulate the immune response in disease states.Overall, the IRAK3 Polyclonal Antibody offers researchers a reliable tool for studying the role of IRAK3 in immune regulation and inflammation, providing valuable insights into potential therapeutic interventions for immune-related disorders.
Product Name:
IRAK3 Rabbit Polyclonal Antibody
SKU:
CAB5467
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 141-596 of human IRAK3 (NP_009130.2).
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11213
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IRAK3 Rabbit pAb (CAB5467) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
