The IRAK1BP1 Polyclonal Antibody (PAC014603) is a valuable tool for researchers studying IRAK1BP1, a protein involved in the regulation of immune responses and inflammation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. Its ability to bind specifically to IRAK1BP1 allows for precise detection and analysis in various cell types, making it an ideal choice for studies in immunology and inflammatory diseases.IRAK1BP1, also known as interleukin-1 receptor-associated kinase 1 binding protein 1, plays a crucial role in modulating the activity of IRAK1, a key player in the signal transduction pathway of the innate immune system.
By inhibiting IRAK1 activity, IRAK1BP1 helps regulate the immune response and prevent excessive inflammation, making it a promising target for therapeutic intervention in conditions such as autoimmune disorders and infections.Investigating the function of IRAK1BP1 with the help of this antibody is essential for gaining insights into immune regulation and developing new treatment strategies for inflammatory diseases. Its specificity and reliability make it an essential tool for researchers looking to advance our understanding of immune system dynamics and potential therapeutic targets.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14603(IRAK1BP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO14603(IRAK1BP1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14603(IRAK1BP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid, protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-α induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Synonyms:
interleukin-1 receptor-associated kinase 1 binding protein 1
UniProt Protein Function:
IRAK1BP1: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Belongs to the IRAK1BP1 family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 6q14-q15Cellular Component: cytoplasm; nucleusBiological Process: I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of transcription, DNA-dependent; immune response
