The IRAK1BP1 Polyclonal Antibody (PAC014602) is a valuable tool for researchers studying IRAK1BP1, a protein involved in the regulation of immune responses. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been verified for use in Western blotting applications. By specifically binding to the IRAK1BP1 protein, this antibody enables precise detection and analysis in various cell types, making it well-suited for investigations in the fields of immunology and cancer research.IRAK1BP1, also known as interleukin-1 receptor-associated kinase 1 binding protein 1, plays a crucial role in modulating immune signaling pathways and regulating inflammatory responses.
Its involvement in immune system function highlights its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and inflammatory conditions. Elucidating the mechanisms of action of IRAK1BP1 is essential for the development of novel treatment strategies aimed at manipulating immune responses in these disease contexts.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14602(IRAK1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal liver tissue, mouse heart tissue, human testis tissue, Primary antibody: PACO14602(IRAK1BP1 Antibody) at dilution 1/475, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14602(IRAK1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid, protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-α induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Synonyms:
interleukin-1 receptor-associated kinase 1 binding protein 1
UniProt Protein Function:
IRAK1BP1: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Belongs to the IRAK1BP1 family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 6q14-q15Cellular Component: cytoplasm; nucleusBiological Process: I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of transcription, DNA-dependent; immune response
