The IQSEC1 Polyclonal Antibody (CAB16725) is a valuable tool for researchers studying the IQSEC1 protein, a guanine nucleotide exchange factor involved in brain development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.IQSEC1 plays a crucial role in regulating neuronal development, synaptic transmission, and plasticity, making it a key player in cognitive functions. Dysregulation of IQSEC1 has been linked to neurological disorders such as intellectual disability and autism spectrum disorders.
Consequently, understanding the function and expression of IQSEC1 is essential for studying these conditions and potentially developing targeted therapies.Ideal for use in neuroscience and developmental biology research, the IQSEC1 Polyclonal Antibody enables precise detection and analysis of IQSEC1 expression in various cell types and tissues. By elucidating the role of IQSEC1 in neuronal development and function, researchers can further our understanding of brain disorders and potentially identify novel therapeutic targets.
Product Name:
IQSEC1 Rabbit Polyclonal Antibody
SKU:
CAB16725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3).
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in nucleolus. Implicated in intellectual developmental disorder with short stature and behavioral abnormalities.
Purification Method:
Affinity purification
Gene ID:
9922
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IQSEC1 Rabbit pAb (CAB16725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
