The IPO8 Polyclonal Antibody (CAB14679) is a valuable tool for researchers studying IPO8, an importin protein crucial for nucleocytoplasmic transport of proteins. Produced in rabbits, this antibody is highly specific for human samples and is validated for use in applications such as Western blotting. By binding to the IPO8 protein, researchers can easily detect and analyze its expression in different cell types, making it an ideal choice for studies in cell biology and gene regulation.IPO8 plays a crucial role in mediating the transport of proteins into the nucleus, regulating important cellular processes such as gene expression and cell signaling.
Its involvement in nucleocytoplasmic shuttling makes it a key player in maintaining cellular homeostasis and function. Research on IPO8 is essential for understanding its role in diseases like cancer, neurodegenerative disorders, and viral infections, where disruptions in nucleocytoplasmic transport can have detrimental effects on cell function and viability. By investigating IPO8, researchers can uncover new insights into cellular transport mechanisms and potentially identify novel therapeutic targets for a variety of diseases.
Product Name:
IPO8 Rabbit Polyclonal Antibody
SKU:
CAB14679
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 878-1037 of human IPO8 (NP_006381.2).
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10526
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IPO8 Rabbit pAb (CAB14679) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
