IPO7 Rabbit Polyclonal Antibody (CAB18417)
- SKU:
- CAB18417
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | IPO7 Rabbit Polyclonal Antibody |
SKU: | CAB18417 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human IPO7 (NP_006382.1). |
Sequence: | ELGS DEDD IDED GQEY LEIL AKQA GEDG DDED WEED DAEE TALE GYST IIDD EDNP VDEY QIFK AIFQ TIQN RNPV WYQA LTHG LNEE QRKQ LQDI ATLA DQRR AAHE SKMI EKHG GYKF SAPV VPSS FNFG GPAP GMN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | Imp7; RANBP7; IPO7 |
Positive Sample: | U-251MG,HepG2,HeLa,Mouse heart,Mouse brain,Rat brain |
Cellular Localization: | cytosol, nuclear envelope, nuclear pore, nucleoplasm |
Calculated MW: | 120kDa |
Observed MW: | 130kDa |
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Purification Method: | Affinity purification |
Gene ID: | 10527 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |