The IP3R Rabbit Monoclonal Antibody (CAB4436) is a high-quality antibody designed for research involving the IP3R protein, a key player in cellular signaling pathways and calcium regulation. This antibody, generated using rabbit monoclonal technology, is highly specific and sensitive, making it ideal for use in various applications such as Western blot, immunofluorescence, and immunohistochemistry.The IP3R protein, also known as inositol trisphosphate receptor, is a critical component in the regulation of intracellular calcium levels, impacting cell signaling, apoptosis, and cell proliferation. Dysregulation of IP3R has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting the IP3R protein with this antibody, researchers can gain valuable insights into its function and potential therapeutic implications in these disease contexts.The IP3R Rabbit Monoclonal Antibody (CAB4436) is an essential tool for researchers studying cellular signaling, calcium dynamics, and diseases involving IP3R dysregulation. Its high specificity and sensitivity provide reliable results for precise detection and analysis of the IP3R protein in different cell types and tissues, advancing our understanding of its role in health and disease.
Product Name:
IP3R Rabbit Monoclonal Antibody
SKU:
CAB4436
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2200-2300 of human IP3R (Q14643).
Endoplasmic reticulum membrane, Cytoplasm, perinuclear region, Cytoplasm, perinuclear region
Calculated MW:
314kDa
Observed MW:
320kDa
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3708
Clone Number:
ARC1007
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using IP3R Rabbit mAb (CAB4436) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
