The Inversin Polyclonal Antibody (CAB10298) is a valuable tool for research involving Inversin, a protein that plays a crucial role in kidney development and polycystic kidney disease. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including immunohistochemistry and immunofluorescence.Inversin is known for its involvement in the formation of primary cilia, microtubule-based organelles that are essential for cellular signaling and development. Dysregulation of Inversin has been linked to abnormal ciliary function and the development of polycystic kidney disease, a genetic disorder characterized by the formation of fluid-filled cysts in the kidneys.
By targeting Inversin, researchers can gain insights into the molecular mechanisms underlying kidney development and disease, paving the way for the development of potential therapies for polycystic kidney disease and other related conditions. The Inversin Polyclonal Antibody is an essential tool for studying Inversin function in both normal and diseased states, making it invaluable for researchers in the field of kidney biology and genetics.
Product Name:
INVS Rabbit Polyclonal Antibody
SKU:
CAB10298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human INVS (NP_055240.2).
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
27130
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using INVS antibody (CAB10298) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
