The Intu Polyclonal Antibody is a vital tool for researchers studying the CD300A protein, a key player in immune regulation. This antibody, generated in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications. By targeting the CD300A protein, researchers can effectively detect and analyze this molecule in a variety of cell types, making it an invaluable tool for studies in immunology and cancer research.CD300A, also known as an immune inhibitory receptor, is instrumental in maintaining immune balance by regulating inflammation and suppressing allergic responses.
Given its crucial role in immune response modulation, CD300A is an attractive target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the functions of CD300A is essential for the development of novel therapies that aim to manipulate immune function in these disease contexts.Order the Intu Polyclonal Antibody today and unlock new insights into the role of CD300A in immune regulation and disease pathogenesis. Accelerate your research with this reliable and sensitive antibody designed to enhance your understanding of immune modulation mechanisms.
IHC image of PACO60436 diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO60436 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO60436 diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.
Synonyms:
Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6), INTU, KIAA1284 PDZD6 PDZK6
