The INTS6 Polyclonal Antibody (CAB6634) is an essential tool for researchers studying the INTS6 protein, which plays a key role in DNA repair and genome stability. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the INTS6 protein, this antibody allows for the detection and analysis of INTS6 expression in a variety of cell types, making it an ideal reagent for research in the fields of molecular biology and oncology.INTS6 is a crucial player in the cellular response to DNA damage, functioning as part of the Integrator complex involved in RNA processing and DNA repair pathways.
Dysregulation of INTS6 has been implicated in various human diseases, including cancer and genetic disorders. Therefore, studying the expression and function of INTS6 is essential for advancing our understanding of these conditions and developing targeted therapies. The availability of the INTS6 Polyclonal Antibody offers researchers a valuable tool to further investigate the roles of INTS6 in health and disease.
Product Name:
INTS6 Rabbit Polyclonal Antibody
SKU:
CAB6634
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human INTS6 (NP_036273.1).
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using INTS6 antibody (CAB6634) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
