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INTS3 Antibody (PACO09972)

SKU:
PACO09972
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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INTS3 Antibody (PACO09972)

The INTS3 Polyclonal Antibody (PACO09972) is a vital tool for researchers studying the INTS3 protein, a key component of the Integrator complex involved in the processing of small nuclear RNAs. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting INTS3 in human samples, making it suitable for use in Western blot and immunohistochemistry applications.INTS3 plays a crucial role in RNA processing and transcription regulation, making it a valuable target for investigation in the fields of molecular biology and gene expression.

By studying INTS3 function and expression levels, researchers can gain insights into its involvement in various cellular processes and diseases, such as cancer and developmental disorders.With its proven reliability and versatility, the INTS3 Polyclonal Antibody is an essential tool for researchers seeking to explore the intricate mechanisms of RNA processing and gene regulation. Unlocking the mysteries of INTS3 can provide valuable insights into biological pathways and potential therapeutic targets for a range of human diseases.

Antibody Name:INTS3 Antibody (PACO09972)
Antibody SKU:PACO09972
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human INTS3
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:integrator complex subunit 3;INTS3;C1orf193;C1orf60;DKFZp686E1950;DKFZp686O20115;DKFZp781I1253;FLJ21919;FLJ44849;INT3 ;
UniProt Protein Function:INTS3: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 3 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: integrator complex; nucleus

Molecular Function:protein binding

Biological Process: DNA repair; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation; snRNA processing

NCBI Summary:INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
UniProt Code:Q68E01
NCBI GenInfo Identifier:39995084
NCBI Gene ID:65123
NCBI Accession:NP_075391.3
UniProt Secondary Accession:Q68E01,Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1 Q69YR5, A8K1W0, B4DQC8, B4E3U9, D3DV57,
UniProt Related Accession:Q68E01
Molecular Weight:63,586 Da
NCBI Full Name:integrator complex subunit 3
NCBI Synonym Full Names:integrator complex subunit 3
NCBI Official Symbol:INTS3  
NCBI Official Synonym Symbols:INT3; SOSSA; SOSS-A; C1orf60; C1orf193  
NCBI Protein Information:integrator complex subunit 3
UniProt Protein Name:Integrator complex subunit 3
UniProt Synonym Protein Names:SOSS complex subunit A; Sensor of single-strand DNA complex subunit A; SOSS-A; Sensor of ssDNA subunit A
Protein Family:Integrator complex
UniProt Gene Name:INTS3  
UniProt Entry Name:INT3_HUMAN

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