The INTS2 Polyclonal Antibody (PACO04821) is a powerful tool for researchers studying INTS2, a key protein involved in DNA replication and repair processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the INTS2 protein, researchers can effectively investigate its role in maintaining genomic stability and its potential implications in diseases such as cancer and genetic disorders.INTS2, also known as Integrator Complex Subunit 2, is essential for proper functioning of the integrator complex, which plays a crucial role in RNA polymerase II transcription.
Dysregulation of INTS2 has been linked to various diseases, highlighting the importance of studying its function and molecular interactions. With the INTS2 Polyclonal Antibody, researchers can delve deeper into the biological mechanisms involving INTS2, ultimately advancing our understanding of gene expression regulation and disease development.
Antibody Name:
INTS2 Antibody
Antibody SKU:
PACO04821
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human INTS2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
INTS2: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 2 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 17q23.2Cellular Component: integral to membrane; integrator complex; intracellular; membrane; nuclear membraneMolecular Function: protein bindingBiological Process: snRNA processing
UniProt Protein Details:
NCBI Summary:
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
