The INTS11 Polyclonal Antibody (CAB10007) is specialized for research involving INTS11, a key component of the integrator complex that plays a crucial role in RNA processing and transcription regulation. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in various applications such as Western blot and immunofluorescence. By targeting the INTS11 protein, this antibody allows for the detection and analysis of INTS11 expression in different cell types, making it ideal for studies in genetics and molecular biology.
INTS11 is essential for the proper functioning of the integrator complex, which is involved in processing non-coding RNAs and regulating gene expression. Dysregulation of INTS11 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for research aimed at understanding disease mechanisms and developing potential therapeutic strategies. The INTS11 Polyclonal Antibody is a valuable tool for investigating the role of INTS11 in gene regulation and its implications for human health.
Product Name:
INTS11 Polyclonal Antibody
SKU:
CAB22031
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 331-600 of human INTS11 (NP_060341.2).
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).
Purification Method:
Affinity purification
Gene ID:
54973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of 293F cells, using INTS11 antibody (CAB22031) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
