UniProt Protein Function: | INTS1: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 1 family.Protein type: RNA processing; Membrane protein, integralChromosomal Location of Human Ortholog: 7p22.3Cellular Component: nuclear membrane; membrane; integral to membrane; integrator complexBiological Process: snRNA processing; negative regulation of caspase activity; inner cell mass cell proliferation |
UniProt Protein Details: | |
NCBI Summary: | INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8N201 |
NCBI GenInfo Identifier: | 97052424 |
NCBI Gene ID: | 26173 |
NCBI Accession: | Q8N201.2 |
UniProt Secondary Accession: | Q8N201,Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8 Q9Y3W8, A6NJ44 |
UniProt Related Accession: | Q8N201 |
Molecular Weight: | 244,297 Da |
NCBI Full Name: | Integrator complex subunit 1 |
NCBI Synonym Full Names: | integrator complex subunit 1 |
NCBI Official Symbol: | INTS1Â Â |
NCBI Official Synonym Symbols: | INT1; NET28Â Â |
NCBI Protein Information: | integrator complex subunit 1 |
UniProt Protein Name: | Integrator complex subunit 1 |
UniProt Synonym Protein Names: | |
Protein Family: | Integrator complex |
UniProt Gene Name: | INTS1Â Â |
UniProt Entry Name: | INT1_HUMAN |