Anti-IL-8 Antibody (CAB2541)
- SKU:
- CAB2541
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-IL-8 Antibody (CAB2541)
The Interleukin-8 Polyclonal Antibody (CAB2541) is a valuable tool for researchers studying interleukin-8 (IL-8), a chemokine involved in inflammation and immune response. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in various applications such as Western blotting.IL-8, a potent chemoattractant for neutrophils and other immune cells, plays a crucial role in inflammatory processes and has been implicated in various diseases, including cancer and inflammatory disorders.
By targeting IL-8, researchers can gain insight into the mechanisms underlying these pathologies and develop novel therapeutic strategies.With its ability to detect and analyze IL-8 protein in different cell types, the Interleukin-8 Polyclonal Antibody (CAB2541) is a valuable asset for studies in immunology, oncology, and inflammatory diseases. By understanding the role of IL-8 in immune regulation and disease progression, researchers can pave the way for new diagnostic tools and targeted therapies.
| Antibody Name: | IL8 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB2541 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-99 of human IL8 (NP_000575.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | Recombinant Human IL-8 Protein, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-99 of human IL8 (NP_000575.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGAV LPRS AKEL RCQC IKTY SKPF HPKF IKEL RVIE SGPH CANT EIIV KLSD GREL CLDP KENW VQRV VEKF LKRA ENS |
| Gene ID: | 3576 |
| Uniprot: | P10145 |
| Cellular Location: | Secreted |
| Calculated MW: | 11kDa |
| Observed MW: | 11KDa |
| Synonyms: | CXCL8, GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 |
| Background: | The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. |
| UniProt Protein Function: | IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q13-q21 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; chemokine activity; interleukin-8 receptor binding Biological Process: regulation of cell adhesion; neutrophil chemotaxis; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; unfolded protein response; calcium-mediated signaling; chemotaxis; signal transduction; regulation of retroviral genome replication; induction of positive chemotaxis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; response to molecule of bacterial origin; receptor internalization; immune response; angiogenesis; cell cycle arrest; cell motility; inflammatory response; embryonic gut development |
| NCBI Summary: | The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10145 |
| NCBI GenInfo Identifier: | 124359 |
| NCBI Gene ID: | 3576 |
| NCBI Accession: | P10145.1 |
| UniProt Secondary Accession: | P10145,Q6FGF6, Q6LAE6, Q96RG6, Q9C077, Q9UCE1, Q9UCR8 Q9UCR9, Q9UCS0, B2R4L8, |
| UniProt Related Accession: | P10145 |
| Molecular Weight: | 11,338 Da |
| NCBI Full Name: | Interleukin-8 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 8 |
| NCBI Official Symbol: | CXCL8Â Â |
| NCBI Official Synonym Symbols: | IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1Â Â |
| NCBI Protein Information: | interleukin-8; emoctakin; interleukin 8; T-cell chemotactic factor; neutrophil-activating peptide 1; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; tumor necrosis factor-induced gene 1; alveolar macrophage chemotactic factor I; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lymphocyte derived neutrophil activating peptide; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide |
| UniProt Protein Name: | Interleukin-8 |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil chemotactic factor; MDNCF; Monocyte-derived neutrophil-activating peptide; MONAP; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; T-cell chemotactic factorCleaved into the following 7 chains:MDNCF-aAlternative name(s):GCP/IL-8 protein IV; IL8/NAP1 form I |
| UniProt Gene Name: | CXCL8Â Â |
| UniProt Entry Name: | IL8_HUMAN |
 | Western blot analysis of extracts of Rat lung, using IL8 antibody (CAB2541) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Western blot analysis of extracts of Recombinant Human IL-8 Protein, using IL8 antibody (CAB2541) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human appendix using IL8 Rabbit pAb (CAB2541) at dilution of 1:100 (40x lens). |
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