The Interleukin-6 Polyclonal Antibody (CAB11115) is a valuable tool for researchers studying Interleukin-6 (IL-6), a cytokine involved in inflammation and immune response regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to IL-6, this antibody enables accurate detection and analysis of the cytokine in a variety of cell types, making it ideal for investigations in immunology, inflammation, and cancer research.IL-6 is a key player in the regulation of the immune response, influencing processes such as inflammation, hematopoiesis, and the acute phase response.
Dysregulation of IL-6 signaling has been implicated in various diseases, including autoimmune disorders, cardiovascular diseases, and cancer. By studying the expression and activity of IL-6 using this antibody, researchers can gain insights into the role of this cytokine in health and disease, potentially leading to the development of novel therapeutic approaches targeting IL-6 signaling pathways.
Product Name:
IL6 Rabbit Polyclonal Antibody
SKU:
CAB11115
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human IL6 (NP_000591.1).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2).
Purification Method:
Affinity purification
Gene ID:
3569
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with IL6 using IL6 Rabbit pAb(CAB11115) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
