The Interleukin-17A (IL-17A) Polyclonal Antibody (CAB0688) is a valuable tool for researchers studying IL-17A, a cytokine involved in inflammatory response and autoimmune conditions. This antibody, produced in rabbits, has high specificity for human samples and is suitable for use in Western blot applications. By binding to IL-17A, it allows for accurate detection and analysis in various cell types, making it ideal for investigations in immunology and inflammatory disease research.
IL-17A is a key player in the immune system, driving inflammation and recruiting immune cells to sites of infection or tissue damage. Dysregulation of IL-17A has been implicated in various autoimmune disorders, such as psoriasis and rheumatoid arthritis, making it an attractive target for therapeutic intervention. Research into the mechanisms of IL-17A activity is crucial for developing new treatments for these conditions and improving our understanding of inflammatory pathways.
Product Name:
IL17A Rabbit Polyclonal Antibody
SKU:
CAB0688
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
Purification Method:
Affinity purification
Gene ID:
3605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IL17A Rabbit pAb (CAB0688) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
