The Integrin Beta 7 Polyclonal Antibody (CAB5873) is a valuable tool for researchers studying integrin beta 7, a cell surface protein involved in cell adhesion and migration. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.Integrin beta 7 plays a crucial role in the immune response by mediating the trafficking of immune cells to the gut mucosa. Dysregulation of integrin beta 7 has been implicated in various inflammatory and autoimmune diseases, making it a promising target for therapeutic intervention.
By using the Integrin Beta 7 Polyclonal Antibody, researchers can accurately detect and analyze the expression of integrin beta 7 in different cell types and tissues. This antibody is essential for studies in immunology, inflammation, and gastrointestinal diseases, providing valuable insights into the role of integrin beta 7 in health and disease.
Product Name:
ITGB7 Rabbit Polyclonal Antibody
SKU:
CAB5873
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ITGB7 (NP_000880.1).
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
3695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ITGB7 Rabbit pAb (CAB5873) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
