Anti-ITGB5 Antibody (CAB2497)
- SKU:
- CAB2497
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-ITGB5 Antibody (CAB2497)
The Integrin Beta 5 Polyclonal Antibody (CAB2497) is a valuable tool for researchers studying integrin beta 5, a cell surface receptor involved in cell adhesion and signaling. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the integrin beta 5 protein, this antibody allows for the detection and analysis of integrin beta 5 expression in various cell types, making it ideal for studies in cell biology and cancer research.Integrin beta 5 is known to play a crucial role in cell migration, invasion, and angiogenesis, making it a key player in tumor progression and metastasis.
Understanding the function and regulation of integrin beta 5 is important for developing targeted therapies for cancer and other diseases involving abnormal cell adhesion and migration.Overall, the Integrin Beta 5 Polyclonal Antibody is a valuable tool for researchers investigating the role of integrin beta 5 in cell biology and disease, providing insight into potential therapeutic targets for conditions such as cancer.
| Antibody Name: | Anti-ITGB5 Antibody |
| Antibody SKU: | CAB2497 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-720 of human ITGB5 (NP_002204.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Mouse liver, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-720 of human ITGB5 (NP_002204.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SPGY LGTR CECQ DGEN QSVY QNLC REAE GKPL CSGR GDCS CNQC SCFE SEFG KIYG PFCE CDNF SCAR NKGV LCSG HGEC HCGE CKCH AGYI GDNC NCST DIST CRGR DGQI CSER GHCL CGQC QCTE PGAF GEMC EKCP TCPD ACST KRDC VECL LLHS GKPD NQTC HSLC RDEV ITWV DTIV KDDQ EAVL CFYK TAKD CVMM FTYV ELPS GKSN LTVL REPE CGNT PNA |
| Gene ID: | 3693 |
| Uniprot: | P18084 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 88kDa |
| Observed MW: | 92kDa |
| Synonyms: | ITGB5 |
| Background: |
| UniProt Protein Function: | ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 3q21.2 Cellular Component: cell surface; focal adhesion; phagocytic vesicle; plasma membrane; receptor complex Molecular Function:protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-matrix adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; muscle contraction; stress fiber formation; transforming growth factor beta receptor signaling pathway |
| UniProt Code: | P18084 |
| NCBI GenInfo Identifier: | 124970 |
| NCBI Gene ID: | 3693 |
| NCBI Accession: | P18084.1 |
| UniProt Secondary Accession: | P18084,B0LPF8, B2RD70, |
| UniProt Related Accession: | P18084 |
| Molecular Weight: | 88,054 Da |
| NCBI Full Name: | Integrin beta-5 |
| NCBI Synonym Full Names: | integrin subunit beta 5 |
| NCBI Official Symbol: | ITGB5Â Â |
| NCBI Protein Information: | integrin beta-5 |
| UniProt Protein Name: | Integrin beta-5 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGB5Â Â |
| UniProt Entry Name: | ITB5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITGB5 antibody (CAB2497) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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