The Integrin Beta 4 Rabbit Monoclonal Antibody (CAB4596) is a high-quality antibody designed for researchers studying integrin beta 4, a cell adhesion molecule involved in cell signaling and migration. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in immunohistochemistry and flow cytometry applications.Integrin beta 4 is a key player in various cellular processes, including wound healing, tumor invasion, and angiogenesis. By targeting integrin beta 4 with this antibody, researchers can detect and study its expression in different cell types, providing valuable insights into its role in cancer progression and metastasis.
This antibody is an essential tool for investigations in cell biology, oncology, and vascular biology.Overall, the Integrin Beta 4 Rabbit Monoclonal Antibody (CAB4596) is a reliable reagent for scientists looking to explore the functions and mechanisms of integrin beta 4 in normal physiological processes and pathological conditions. Its specificity and sensitivity make it an excellent choice for research focused on understanding the role of integrin beta 4 in cancer and other diseases.
Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein, hemidesmosome.
Calculated MW:
202kDa
Observed MW:
210kDa
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3691
Clone Number:
ARC1046
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Integrin beta 4 (ITGB4/CD104) Rabbit mAb (CAB4596) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
