The Integrin Beta 4 (ITGB4/CD104) Polyclonal Antibody is a valuable tool for researchers studying integrins and cell adhesion. Integrin Beta 4 is a cell surface receptor involved in various biological processes, including cell migration, proliferation, and survival. This polyclonal antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.By targeting the ITGB4 protein, this antibody enables the detection and analysis of integrin Beta 4 expression in different cell types, providing insights into its role in cell adhesion and signaling.
Integrin Beta 4 is known to be involved in the regulation of epithelial cell behavior and has implications in various pathologies, including cancer metastasis and skin blistering disorders.The ITGB4 Polyclonal Antibody is a valuable tool for researchers interested in understanding the molecular mechanisms that govern cell adhesion and migration. Its specificity and reliability make it an essential reagent for studies in cell biology, cancer research, and tissue engineering.
Product Name:
Integrin beta 4 (ITGB4/CD104) Polyclonal Antibody
SKU:
CAB21469
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 28-310 of human Integrin beta 4 (ITGB4/CD104) (NP_000204.3).
Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein, hemidesmosome.
Calculated MW:
202kDa
Observed MW:
Refer to figures
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3691
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Integrin beta 4 (ITGB4/CD104) Rabbit pAb (CAB21469) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
