The Integrin Beta-3 Polyclonal Antibody (CAB2542) is a valuable tool for researchers studying integrin beta-3, a transmembrane receptor protein involved in cell adhesion and signaling processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the integrin beta-3 protein, this antibody enables detection and analysis in a variety of cell types, making it well-suited for investigations in cell biology, developmental biology, and cancer research.Integrin beta-3 plays a critical role in mediating cell adhesion to the extracellular matrix, as well as facilitating cell migration and invasion in various physiological and pathological processes.
Dysregulation of integrin beta-3 expression and activity has been implicated in diseases such as cancer, cardiovascular disorders, and osteoporosis, highlighting its potential as a therapeutic target. Researchers interested in elucidating the molecular mechanisms underlying these diseases can benefit from using the Integrin Beta-3 Polyclonal Antibody to explore the function and regulation of integrin beta-3 in different biological contexts.
Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, focal adhesion, lamellipodium membrane.
Calculated MW:
87kDa
Observed MW:
100kDa
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Purification Method:
Affinity purification
Gene ID:
3690
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Integrin beta 3 (ITGB3/CD61) Rabbit pAb (CAB2542) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
