Integrin alpha V (ITGAV/CD51) Rabbit Polyclonal Antibody (CAB2091)
The Integrin alpha V Polyclonal Antibody (CAB2091) is a versatile tool for researchers studying integrin alpha V, a cell surface receptor involved in cell adhesion and signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications.Integrin alpha V plays a crucial role in diverse biological processes such as cell migration, invasion, and angiogenesis, making it a key target for investigation in various fields including cancer research, developmental biology, and tissue regeneration. By facilitating the detection and analysis of integrin alpha V protein expression in different cell types, this antibody enables researchers to gain insights into the mechanisms underlying these processes.
Moreover, the dysregulation of integrin alpha V has been implicated in various diseases such as cancer, cardiovascular disorders, and inflammatory conditions. Therefore, a better understanding of its function and regulation is essential for the development of targeted therapies aimed at modulating integrin alpha V activity in disease contexts. The Integrin alpha V Polyclonal Antibody (CAB2091) provides a valuable resource for advancing research in these areas and uncovering new therapeutic strategies.
Product Name:
Integrin alpha V (ITGAV/CD51) Rabbit Polyclonal Antibody
SKU:
CAB2091
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 950-1048 of human Integrin alpha V (ITGAV/CD51) (NP_002201.1).
WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
CD51; MSK8; VNRA; VTNR; Integrin alpha V (ITGAV/CD51)
Positive Sample:
MCF7,NIH/3T3,C6
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein.
Calculated MW:
116kDa
Observed MW:
130kDa
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Purification Method:
Affinity purification
Gene ID:
3685
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Integrin alpha V (ITGAV/CD51) Rabbit pAb (CAB2091) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
