The Integrin Alpha M Polyclonal Antibody (CAB1581) is a powerful research tool for scientists studying integrin alpha M, a cell adhesion molecule involved in various biological processes, including immune response and inflammation. This antibody, produced using rabbit immunization, exhibits high specificity and reactivity towards human samples, making it a reliable choice for Western blot applications.Integrin alpha M functions as a receptor for various ligands, mediating cell-cell and cell-extracellular matrix interactions. Its role in immune cell migration and phagocytosis highlights its importance in inflammatory responses and host defense mechanisms.
By targeting integrin alpha M, researchers can uncover new insights into immune system regulation and potentially develop targeted therapies for inflammatory diseases and cancer.With its ability to detect and analyze integrin alpha M protein in different cell types, the CAB1581 antibody is a valuable tool for investigations in immunology, oncology, and inflammation research. By studying the function and regulation of integrin alpha M, scientists can advance our understanding of immune-mediated diseases and explore novel therapeutic strategies for treating these conditions.
Product Name:
CD11b/ITGAM Rabbit Polyclonal Antibody
SKU:
CAB1581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 145-340 of CD11b/ITGAM (NP_000623.2).
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD11b/ITGAM Rabbit pAb (CAB1581) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
