The Integrin Alpha 6 Polyclonal Antibody (CAB3236) is a valuable tool for researchers studying integrin alpha 6, a cell surface receptor involved in cell adhesion and migration processes. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Integrin alpha 6 is a key player in various physiological and pathological processes, such as embryonic development, tissue regeneration, and cancer metastasis. By targeting this protein with the Integrin Alpha 6 Polyclonal Antibody, researchers can detect and analyze its expression and localization in different cell types, providing insights into its functional role in cell behavior.
With its ability to specifically bind to integrin alpha 6, this antibody is ideal for studies in cell biology, cancer research, and developmental biology. By understanding the function and regulation of integrin alpha 6, researchers can gain valuable knowledge that may lead to the development of targeted therapies for various diseases and conditions associated with dysregulated cell adhesion and migration.
Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:
127kDa
Observed MW:
125kDa
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3655
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Integrin alpha 6 (ITGA6/CD49f) antibody (CAB3236) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
