Insulin Receptor Rabbit Polyclonal Antibody (CAB16900)
- SKU:
- CAB16900
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | Insulin Receptor Rabbit Polyclonal Antibody |
SKU: | CAB16900 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1281-1382 of human INSR (NP_000199.2). |
Sequence: | PTFL EIVN LLKD DLHP SFPE VSFF HSEE NKAP ESEE LEME FEDM ENVP LDRS SHCQ REEA GGRD GGSS LGFK RSYE EHIP YTHM NGGK KNGR ILTL PRSN PS |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HHF5; CD220; Insulin Receptor |
Positive Sample: | HepG2,HeLa,Mouse brain,Mouse kidney |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 156kDa |
Observed MW: | 110kDa/220kDa |
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |