The Insulin Receptor Rabbit Monoclonal Antibody (CAB19067) is a specialized tool for studying the insulin receptor, a key player in regulating blood sugar levels and metabolism. This antibody, developed from rabbit immune cells, exhibits high specificity for the human insulin receptor and is suitable for various research applications, including Western blotting.The insulin receptor is a critical protein involved in controlling glucose uptake and metabolism in cells, making it a target of interest in diabetes and metabolic disorders. By using this antibody, researchers can accurately detect and analyze the insulin receptor in different cell types, paving the way for advancements in diabetes research and drug development.
Furthermore, understanding the mechanisms underlying insulin receptor function is essential for improving treatments for diabetes and related conditions. By utilizing the Insulin Receptor Rabbit Monoclonal Antibody (CAB19067), scientists can expand their knowledge of insulin signaling pathways and identify new therapeutic targets for managing metabolic diseases.
Product Name:
Insulin Receptor Rabbit Monoclonal Antibody
SKU:
CAB19067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human Insulin Receptor (P06213).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
156kDa
Observed MW:
100kDa
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3643
Clone Number:
ARC0458
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Insulin Receptor antibody (CAB19067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
