The Insulin Receptor Polyclonal Antibody (CAB21466) is a valuable tool for researchers studying the insulin receptor, a key player in glucose metabolism and cell signaling. This antibody, produced in rabbits, is highly specific for human insulin receptor samples and is validated for use in Western blot applications.The insulin receptor plays a crucial role in regulating glucose uptake and metabolism in cells, making it a vital target for research into diabetes, metabolic disorders, and cancer. By binding to the insulin receptor protein, this antibody enables researchers to detect and analyze its expression and activity in various cell types, providing valuable insights into its function.
Understanding the role of the insulin receptor is essential for developing therapies that target insulin signaling pathways for the treatment of metabolic diseases and cancer. With its reliable performance in Western blot assays, the Insulin Receptor Polyclonal Antibody is an essential tool for advancing research in these areas.
Product Name:
Insulin Receptor Polyclonal Antibody
SKU:
CAB21466
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 475-570 of human Insulin Receptor (NP_000199.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
156kDa
Observed MW:
95kDa
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3643
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Insulin Receptor Rabbit pAb (CAB21466) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
