Phospho-INSR-Y1150/IGF1R-Y1135 Rabbit Polyclonal Antibody (CABP0044)
- SKU:
- CABP0044
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
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Description
Product Name: | Phospho-INSR-Y1150/IGF1R-Y1135 Rabbit Polyclonal Antibody |
SKU: | CABP0044 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around Y1150 of human IGF1RINSR (NP_001073285.1). |
Sequence: | TDYY R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | IGF1R/INSR; Phospho-INSR-Y1150/IGF1R-Y1135 |
Positive Sample: | 293,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, nucleus, plasma membrane, T-tubule |
Calculated MW: | 154kDa/155kDa/156kDa |
Observed MW: | 80kDa |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Purification Method: | Affinity purification |
Gene ID: | 3480/3643 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |