The INSR/IGF1R Monoclonal Antibody is a crucial tool for researchers studying insulin and insulin-like growth factor receptors in various biological processes. This antibody, developed for use in Western blot applications, specifically targets the INSR/IGF1R protein, allowing for accurate detection and analysis in different samples.The functionality of INSR and IGF1R receptors is essential for the regulation of various cellular functions, including growth, metabolism, and differentiation. Dysregulation of these receptors has been linked to diseases such as diabetes, cancer, and metabolic disorders.
By using the INSR/IGF1R Monoclonal Antibody, researchers can gain valuable insights into the role of these receptors in health and disease.Overall, this antibody is a reliable tool for researchers in the fields of endocrinology, oncology, and cell biology who are interested in studying the intricate mechanisms involving INSR and IGF1R receptors. Its high specificity and sensitivity make it an ideal choice for various research applications.
axon, caveola, dendrite membrane, external side of plasma membrane, extracellular exosome, late endosome, lysosome, plasma membrane
Calculated MW:
156kDa
Observed MW:
97kDa
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3643/ 3480
Clone Number:
ARC54074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using INSR/IGF1R Rabbit mAb (CAB21984) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
