The Insig2 Polyclonal Antibody (CAB1992) is a valuable tool for researchers studying Insig2, a key protein involved in lipid metabolism and cholesterol homeostasis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to Insig2, this antibody allows for the detection and analysis of Insig2 protein levels in various cell types, making it ideal for studies in metabolic disorders, cardiovascular diseases, and lipid-related research.Insig2 is a crucial regulator of cholesterol biosynthesis and plays a significant role in the control of lipid metabolism. Dysregulation of Insig2 has been linked to conditions such as obesity, insulin resistance, and dyslipidemia, making it an attractive target for therapeutic interventions aimed at improving metabolic health.
Understanding the function of Insig2 is essential for developing strategies to treat and prevent metabolic diseases that pose a significant public health burden worldwide.Overall, the Insig2 Polyclonal Antibody (CAB1992) provides researchers with a reliable tool to investigate the role of Insig2 in various physiological and pathological processes related to lipid metabolism and cholesterol homeostasis. Its specificity and sensitivity make it a valuable asset for studies in metabolic disorders and cardiovascular diseases, offering new insights into potential therapeutic targets for improving human health.
Product Name:
INSIG2 Rabbit Polyclonal Antibody
SKU:
CAB1992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human INSIG2 (NP_057217.2).
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
Purification Method:
Affinity purification
Gene ID:
51141
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using INSIG2 Rabbit pAb (CAB1992) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
