INSIG1 Rabbit Polyclonal Antibody (CAB16278)
- SKU:
- CAB16278
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | INSIG1 Rabbit Polyclonal Antibody |
SKU: | CAB16278 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human INSIG1 (NP_005533.2). |
Sequence: | LWWT FDRS RSGL GLGI TIAF LATL ITQF LVYN GVYQ YTSP DFLY IRSW LPCI FFSG GVTV GNIG RQLA MGVP EKPH SD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CL6; INSIG1 |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | endoplasmic reticulum |
Calculated MW: | 30kDa |
Observed MW: | 36kDa |
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3638 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |