The INSC Antibody (PACO09967) is a highly specific polyclonal antibody designed for research involving INSC, a protein involved in regulating insulin secretion in pancreatic beta cells. This antibody, produced in rabbits, has been validated for use in various research applications, including Western blot and immunohistochemistry.INSC, also known as INSM1, is a key transcription factor that plays a crucial role in the development and function of pancreatic beta cells. It is involved in the regulation of insulin gene expression and secretion, making it a critical target for studies related to diabetes and metabolic disorders.
The INSC Antibody (PACO09967) enables researchers to detect and analyze the expression of INSC in various cell types, providing valuable insights into its function and role in insulin secretion. Its high specificity and sensitivity make it an ideal tool for investigations into diabetes pathogenesis and potential therapeutic interventions targeting the insulin signaling pathway.
INSC: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11p15.2
UniProt Protein Details:
NCBI Summary:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
