INPP5E Rabbit Polyclonal Antibody (CAB17735)
- SKU:
- CAB17735
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | INPP5E Rabbit Polyclonal Antibody |
SKU: | CAB17735 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-630 of human INPP5E (NP_063945.2). |
Sequence: | LIRE MRKG SIFK GFQE PDIH FLPS YKFD IGKD TYDS TSKQ RTPS YTDR VLYR SRHK GDIC PVSY SSCP GIKT SDHR PVYG LFRV KVRP GRDN IPLA AGKF DREL YLLG IKRR ISKE IQRQ Q |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin; INPP5E |
Positive Sample: | SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | axoneme, cilium, cytosol, focal adhesion, Golgi apparatus, nucleoplasm, nucleus, plasma membrane |
Calculated MW: | 70kDa |
Observed MW: | 80kDa |
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 56623 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |