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SHIP1 Rabbit Polyclonal Antibody (CAB0122)

SKU:
CAB0122
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-INPP5D Antibody CAB0122
  • Cell Death Antibodies 1 Anti-INPP5D Antibody CAB0122
€139 - €419
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Description

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SHIP1 Rabbit Polyclonal Antibody (CAB0122)

The INPP5D Polyclonal Antibody (CAB0122) is specifically designed for researchers studying the INPP5D gene, also known as SHIP-1. INPP5D plays a crucial role in regulating immune cell signaling and is implicated in various immune-related diseases. This antibody is produced in rabbits and has been validated for use in Western blot applications, where it demonstrates high reactivity with human samples. By binding to the INPP5D protein, this antibody enables precise detection and analysis in a variety of cell types.

Researchers in immunology, cancer research, and autoimmune disorders will find the INPP5D Polyclonal Antibody invaluable for understanding the molecular mechanisms underlying immune regulation and disease pathogenesis. By elucidating the function of INPP5D, researchers may uncover new therapeutic targets and strategies for treating immune-related disorders.

Product Name:SHIP1 Rabbit Polyclonal Antibody
SKU:CAB0122
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human SHIP1 (NP_001017915.1).
Sequence:PPCS GSSI TEII NPNY MGVG PFGP PMPL HVKQ TLSP DQQP TAWS YDQP PKDS PLGP CRGE SPPT PPGQ PPIS PKKF LPST ANRG LPPR TQES RPSD LGKN A
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
Positive Sample:Mouse spleen
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Membrane, Peripheral membrane protein.
Calculated MW:133kDa
Observed MW:140kDa

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3635
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse spleen, using SHIP1 Rabbit pAb (CAB0122) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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