The INMT Polyclonal Antibody (CAB14391) is a valuable tool for researchers studying the INMT protein, which plays a key role in various cellular processes. The antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot experiments. By specifically binding to the INMT protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and drug development.
INMT, or Indolethylamine N-Methyltransferase, is an enzyme involved in the biosynthesis of melatonin and other important metabolites. Its functions in neurotransmitter metabolism and cellular regulation make it a promising target for investigating neurological disorders, sleep disorders, and potential therapeutic interventions. By elucidating the mechanisms of INMT activity, researchers can gain valuable insights into the underlying pathways of these conditions and explore new treatment strategies.
Product Name:
INMT Rabbit Polyclonal Antibody
SKU:
CAB14391
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human INMT (NP_006765.4).
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera.
Purification Method:
Affinity purification
Gene ID:
11185
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using INMT Rabbit pAb (CAB14391) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
