The ING5 Polyclonal Antibody (CAB7288) is specifically designed for research involving ING5, a tumor suppressor protein that plays a critical role in regulating cell growth and apoptosis. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ING5 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal tool for studies in cancer research and cell biology.ING5 is known to interact with histone deacetylases and histone acetyltransferases, playing a key role in chromatin remodeling and gene transcription regulation.
Dysregulation of ING5 has been associated with various types of cancer, making it a promising target for therapeutic interventions. Research on ING5 can provide insights into the mechanisms of tumorigenesis and potentially lead to the development of novel cancer treatments targeting this important protein.Overall, the ING5 Polyclonal Antibody is a valuable tool for researchers studying the role of ING5 in cancer biology and chromatin remodeling. Its high specificity and sensitivity make it a reliable reagent for investigating the functions of ING5 and its potential implications in cancer development and progression.
Product Name:
[KO Validated] ING5 Rabbit Polyclonal Antibody
SKU:
CAB7288
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ING5 (NP_115705.2).
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
84289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and ING5 knockout (KO) 293T cells, using ING5 antibody (CAB7288) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
