The ING4 Polyclonal Antibody (CAB5833) is a valuable tool for researchers studying the tumor suppressor protein ING4. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It binds to the ING4 protein, allowing for accurate detection and analysis in various cell types, making it an ideal choice for studies in cancer research and molecular biology.ING4 is a key player in regulating cell growth, apoptosis, and DNA repair, making it a crucial target for investigating cancer development and progression. Its tumor-suppressive properties suggest its potential as a therapeutic target for cancer treatment.
By studying the function of ING4, researchers can gain insights into the molecular mechanisms underlying tumorigenesis and identify new approaches for cancer therapy.Overall, the ING4 Polyclonal Antibody is a reliable reagent for exploring the role of ING4 in cancer biology and advancing our understanding of the molecular pathways involved in tumorigenesis. Its specificity and sensitivity make it an essential tool for researchers aiming to unravel the complexities of cancer and develop targeted therapies for improved patient outcomes.
Product Name:
ING4 Rabbit Polyclonal Antibody
SKU:
CAB5833
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human ING4 (NP_001121054.1).
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
Purification Method:
Affinity purification
Gene ID:
51147
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ING4 antibody (CAB5833) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
