The INCA1 Polyclonal Antibody (PACO35230) is a valuable tool for researchers studying the INCA1 protein, a key player in cellular signaling pathways. This antibody, developed in rabbits, shows high reactivity with human samples and is validated for use in various research applications, including Western blotting.INCA1, also known as inhibitor of CDK interacting with cyclin A1, is involved in regulating cell cycle progression and DNA replication. Its role in controlling cell growth and division makes it a crucial target for studies in cancer biology and cell biology.
By targeting the INCA1 protein, researchers can gain insights into the mechanisms underlying cancer development and identify potential therapeutic strategies.Furthermore, understanding the functions of INCA1 can provide valuable information for developing targeted therapies aimed at controlling abnormal cell proliferation and tumor growth. By using the INCA1 Polyclonal Antibody, researchers can explore the complex interactions of this protein and its implications for cancer research and drug development.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO35230 at dilution of 1:100.
Background:
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).
Synonyms:
Protein INCA1 (Inhibitor of CDK interacting with cyclin A1), INCA1
UniProt Protein Function:
INCA1: Belongs to the INCA family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 17p13.2Cellular Component: cytoplasm; nucleusMolecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; cyclin bindingBiological Process: negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity
