The IMPDH2 Rabbit Monoclonal Antibody (CAB9208) is a highly specific and sensitive tool for researchers investigating IMPDH2, an enzyme involved in purine nucleotide biosynthesis and a target in cancer therapy. This antibody, produced in rabbits, has been validated for use in Western blotting and immunohistochemistry applications with human samples.IMPDH2 plays a crucial role in cell proliferation and is upregulated in various types of cancer, making it a promising therapeutic target. This monoclonal antibody binds specifically to IMPDH2, allowing for precise detection and analysis in different cell types, making it an essential tool for studies in cancer biology and drug development.
Understanding the function and regulation of IMPDH2 is essential for developing targeted therapies for cancer and other diseases that rely on purine synthesis for cell growth and survival. This monoclonal antibody provides researchers with a reliable tool to study IMPDH2 and its potential as a therapeutic target in cancer treatment.
Product Name:
IMPDH2 Rabbit Monoclonal Antibody
SKU:
CAB9208
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human IMPDH2 (P12268).
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Purification Method:
Affinity purification
Gene ID:
3615
Clone Number:
ARC1479
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KO Validated] IMPDH2 Rabbit mAb (CAB9208) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
