The IMPDH2 Polyclonal Antibody (CAB5350) is a valuable tool for researchers studying IMPDH2, an enzyme involved in the de novo synthesis of guanine nucleotides and a target for cancer therapy. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blotting applications.IMPDH2 plays a key role in cellular proliferation and is overexpressed in various cancer types, making it a promising target for cancer treatment. The IMPDH2 Polyclonal Antibody binds specifically to the IMPDH2 protein, allowing for accurate detection and quantification in different cell types.
This makes it an excellent choice for studies in oncology and drug development.By understanding the role of IMPDH2 in cancer progression and drug resistance, researchers can develop targeted therapies that inhibit IMPDH2 activity and potentially improve patient outcomes. The IMPDH2 Polyclonal Antibody is a reliable tool for investigating the functions of this enzyme and its potential as a therapeutic target in cancer research.
Product Name:
IMPDH2 Rabbit Polyclonal Antibody
SKU:
CAB5350
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2).
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Purification Method:
Affinity purification
Gene ID:
3615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IMPDH2 antibody (CAB5350) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
