The IMPDH2 Polyclonal Antibody (CAB15626) is a versatile tool for researchers studying IMPDH2, an enzyme involved in the biosynthesis of guanine nucleotides. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the IMPDH2 protein, this antibody allows for the detection and analysis of IMPDH2 levels in various cell types.IMPDH2 plays a crucial role in nucleotide metabolism, making it essential for cell proliferation and growth. Dysregulation of IMPDH2 has been implicated in cancer, viral infections, and immunological disorders.
By studying the expression and activity of IMPDH2, researchers can gain valuable insights into these disease processes and potentially identify new therapeutic targets.With its high specificity and sensitivity, the IMPDH2 Polyclonal Antibody (CAB15626) is a valuable tool for researchers investigating the role of IMPDH2 in health and disease. Whether studying cell proliferation, nucleotide metabolism, or disease pathways, this antibody is an essential component of any research project focused on understanding the functions of IMPDH2.
Product Name:
IMPDH2 Rabbit Polyclonal Antibody
SKU:
CAB15626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2).
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Purification Method:
Affinity purification
Gene ID:
3615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IMPDH2 Rabbit pAb (CAB15626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
