The IMPDH1 Polyclonal Antibody (CAB9497) is a valuable tool for researchers investigating IMPDH1, an enzyme involved in the de novo synthesis of guanine nucleotides and a crucial player in DNA and RNA synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By binding specifically to the IMPDH1 protein, this antibody facilitates the detection and analysis of IMPDH1 in various cell types, making it an essential component for studies in biochemistry and cancer research.
IMPDH1 is a key enzyme in the purine biosynthesis pathway and is essential for cell proliferation and growth. Its dysregulation has been implicated in various diseases, including cancer, viral infections, and autoimmune disorders. As such, understanding the function and regulation of IMPDH1 is crucial for developing targeted therapies for these conditions. The IMPDH1 Polyclonal Antibody provides researchers with a reliable tool to study the role of IMPDH1 in health and disease, paving the way for advancements in personalized medicine and drug discovery.
Product Name:
IMPDH1 Rabbit Polyclonal Antibody
SKU:
CAB9497
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 434-563 of human IMPDH1 (NP_899066.1).
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3614
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IMPDH1 Rabbit pAb (CAB9497) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
