The IMPA1 Polyclonal Antibody (CAB6381) is a valuable tool for researchers studying IMPA1, a key enzyme involved in the regulation of inositol metabolism and cell signaling pathways. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.IMPA1 plays a crucial role in the phosphoinositide signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and intracellular trafficking. Dysregulation of IMPA1 has been associated with a variety of diseases, including bipolar disorder, schizophrenia, and cancer.
By targeting IMPA1 with this polyclonal antibody, researchers can gain valuable insights into the function and regulation of this enzyme in normal and disease states. This antibody enables the detection and analysis of IMPA1 protein levels in different cell types, making it an essential tool for studies in cell biology, neuroscience, and cancer research. Understanding the role of IMPA1 may lead to the development of novel therapeutic strategies for treating diseases associated with dysregulated inositol metabolism.
Product Name:
IMPA1 Rabbit Polyclonal Antibody
SKU:
CAB6381
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1).
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Purification Method:
Affinity purification
Gene ID:
3612
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IMPA1 Rabbit pAb (CAB6381) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
