IMPA1 Rabbit Polyclonal Antibody (CAB6381)
- SKU:
- CAB6381
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | IMPA1 Rabbit Polyclonal Antibody |
SKU: | CAB6381 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1). |
Sequence: | MADP WQEC MDYA VTLA RQAG EVVC EAIK NEMN VMLK SSPV DLVT ATDQ KVEK MLIS SIKE KYPS HSFI GEES VAAG EKSI LTDN PTWI IDPI DGTT NFVH RFPF VAVS IGFA VNKK IEFG VVYS CVEG KMYT ARKG KGAF CNGQ KLQV SQQE DITK SLLV TELG SSRT PETV RMVL SNME KLFC IPVH GIRS VGTA AVNM CLVA TGGA DAYY EMGI HCWD VAGA GIIV TEAG GVLM DVTG GPFD LMSR RVIA ANNR ILAE RIAK EIQV IPLQ RDDE D |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:10 - 1:100 |
Synonyms: | IMP; IMPA; MRT59; IMPA1 |
Positive Sample: | SKOV3,SW620,Jurkat,SH-SY5Y,Mouse liver,Mouse kidney,Mouse brain,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Purification Method: | Affinity purification |
Gene ID: | 3612 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |