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IMPA1 Monoclonal Antibody [PAT2G5AT] (CPAB0226)

SKU:
CPAB0226
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT2G5AT
Applications:
ELISA
FC
$179
Frequently bought together:

Description

system_update_alt Datasheet

IMPA1 Monoclonal Antibody [PAT2G5AT] (CPAB0226)

The IMPA1 Polyclonal Antibody (CPAB0226) is a valuable tool for research involving IMPA1, an enzyme involved in inositol metabolism. This antibody, produced in rabbits, is highly specific to human IMPA1 and has been validated for use in a variety of applications, including Western blotting. By targeting the IMPA1 protein, this antibody allows for the detection and analysis of IMPA1 expression in various cell types, making it a versatile tool for studies in molecular biology and neuroscience.IMPA1 is crucial for the regulation of inositol signaling pathways, which play a role in various cellular processes including cell growth, differentiation, and neurotransmission.

Dysregulation of IMPA1 has been implicated in neurological disorders such as bipolar disorder and schizophrenia, making it a promising target for research in these areas. Understanding the function of IMPA1 is essential for uncovering the mechanisms underlying these disorders and developing potential therapeutic interventions.

Product Name:IMPA1 Antibody
Product Sku:CPAB0226
Size:5μg
Host Species:Mouse
Immunogen:Anti-human IMPA1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IMPA1 protein 1-277amino acids purified from Ecoli.
Clone:PAT2G5AT.
Reactivity:Human
Applications:ELISA, Flow Cytometry
Purification Method:IMPA1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Inositol monophosphatase1 (IMPA1) is responsible for the provision of inositol essential for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 has a central role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. IMPA1 has been recognized as the pharmacological target for lithium action in the brain. The IMPA1 enzyme has a magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and ensuing depletion of inositol for phosphatidylinositol synthesis may perhaps explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder.
Synonyms:Inositol monophosphatase 1, IMP 1, IMPase 1, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1, IMPA1, IMPA, IMP.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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