The IMP2 Rabbit Monoclonal Antibody (CAB5189) is a powerful tool for researchers studying the IMP2 protein, a key player in regulating gene expression and cellular metabolism. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting.IMP2, also known as insulin-like growth factor 2 mRNA-binding protein 2, is involved in post-transcriptional regulation of gene expression and has been implicated in various cellular processes, including cell growth, differentiation, and tumorigenesis.
By targeting IMP2 with this monoclonal antibody, researchers can gain valuable insights into its function and role in diseases such as cancer and metabolic disorders.This antibody enables precise detection and analysis of IMP2 in a variety of cell types, making it an essential tool for studies in molecular biology, cancer biology, and metabolic research. By understanding the role of IMP2, researchers can uncover new therapeutic targets for diseases associated with dysregulated gene expression and metabolism.
Product Name:
IGF2BP2/IMP2 Rabbit Monoclonal Antibody
SKU:
CAB5189
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-595 of human IGF2BP2/IMP2 (NP_001007226.1).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
IMP2; IMP-2; VICKZ2; IGF2BP2/IMP2
Positive Sample:
HT-29,293T,Hep G2
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
66kDa/62kDa
Observed MW:
65kDa/70kDa
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes.
Purification Method:
Affinity purification
Gene ID:
10644
Clone Number:
ARC1203
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF2BP2/IGF2BP2/IMP2 Rabbit mAb (CAB5189) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
